The Museum’s collection of American art includes paintings and sculptures by artists from the colonial era through 1960. Highlights include works by Hans Hofmann, Thomas Moran, Georgia O’Keeffe, and Charles Willson Peale.

The collection includes twenty-eight works donated by the Works Progress Administration in 1942. This gift formed the core collection of the Oklahoma Art Center, the predecessor of the Oklahoma City Museum of Art. The American Art collection includes numerous examples by artists who were active in Oklahoma, such as Oscar Brousse Jacobson, Doel Reed, Nellie Shepherd, and Nan Sheets.

Also represented are later examples by artists such as Isabel Bishop, Jack Levine, and Moses Soyer, who came to prominence during the interwar decades.