The exhibition on domestication presents the changes animals underwent as a result of human interference.

The exhibition starts with a unique sight: visitors are greeted by a skull of a prehistoric aurochs on the right side of the corridor, while a row of Hungarian Grey cattle skulls with enormous horns are placed above the showcases on the left.

To the left original archaeozoological finds and three reconstructed prehistoric scenes are shown. The scenes faithfully depict moments from the life of prehistoric people. The exhibition starts with the demonstration of Paleolithic flora and fauna. There were species that no longer exist in Hungary, such as the cave bear, woolly rhinoceros and mammoth. Humans in this period lived in caves and huts, and acquired their food mainly by hunting and fishing. Visitors can also learn when and where the various species were domesticated. During the Neolithic period the most important domestic animals were sheep, goats, cattle, pigs and dogs. These ancient domestic animals were introduced from the Balkans by the people of the Körös Culture. A further unique feature is that the exhibition displays several thousand year old Neolithic animal statuettes, which were carved by contemporary humans as part of their religion and beliefs.

The showcases on the right demonstrate the changes that each species underwent as a result of domestication. The transformation of the metatarsal bone and skull shape of cattle is especially spectacular. This is where the Hungarian Grey cattle, an important regional type in the 17th-19th centuries, are also presented.

A really outstanding exhibit is the gold cup of Vaphio from 1500 BC, depicting the capture of an aurochs. The skeletons of wild boar and domestic pig show how the number of vertebrae and thus the quantity of chop grows as a result of domestication. The next showcases present the different uses of sheep and horses. Children are also interested in the depictions and skeletons of various dog breeds in the next showcase, which demonstrates the variability and diversity in the stature and head shapes of dogs with the aid of the skulls and bones of different species.